diff --git a/docs/guide/index.rst b/docs/guide/index.rst
index e4dba05f365da657054febec9c7ba39d4440d75c..758329d68fba4a1828e9633a5330ef8ce691473f 100644
--- a/docs/guide/index.rst
+++ b/docs/guide/index.rst
@@ -15,4 +15,5 @@ User Guide
     deploy
     testing
     porting
+    sysdeps
     faq
diff --git a/docs/guide/sysdeps.rst b/docs/guide/sysdeps.rst
new file mode 100644
index 0000000000000000000000000000000000000000..8e7d24ad0d756b35fa73e843880a84da52bc5cbf
--- /dev/null
+++ b/docs/guide/sysdeps.rst
@@ -0,0 +1,22 @@
+System Dependencies
+===================
+
+PyGObject not only depends on packages available from PyPI, but also requires
+certain system dependencies to be installed. Because their version isn't taken
+into account by pip's dependency resolver, you may need to restrict the version
+of PyGObject itself for the installation to succeed. This lists the minimum
+version of the system dependencies over time.
+
+3.46.0+:
+    * glib: >= 2.64.0
+    * gobject-introspection: >= 1.64.0
+    * libffi: >= 3.0
+
+    Example distributions: Ubuntu 20.04, Debian Bullseye, or newer
+
+3.40.0 - 3.44.x:
+    * glib: >= 2.56.0
+    * gobject-introspection: >= 1.56.0
+    * libffi: >= 3.0
+
+    Example distributions: Ubuntu 18.04, or newer