As mentioned there, this is exposed in Gnome Tweaks. It is on by default, but completely break touchpad usage of certain kinds of games and other software requiring simultaneous use of the mouse and keyboard.
I like the idea in the issue of automatically detecting games, but I'm not sure how/if it can be done reliably (and it's not an issue only for games). In lieu of that, it seems good to expose the setting here.
Recent Pop!_OS report related to this: https://github.com/pop-os/pop/issues/1463