Ctrl+S triggers the main search entry, but that doesn't follow HIG
https://gitlab.gnome.org/GNOME/gnome-control-center/-/blob/gnome-43/shell/cc-window.c#L838
Ctrl+S is reserved for the "save" action:
https://developer.gnome.org/hig/reference/keyboard.html
Additional info
- gnome-control-center-43.2-1.fc37.x86_64